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New cancer immunotherapy uses engineered T cells to target a common genetic alteration

New cancer immunotherapy uses engineered T cells to target a common genetic alteration
Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers. The approach, which stimulates an immune response against cells that are missing one gene copy, called loss of heterozygosity (LOH), was developed by researchers at the Ludwig Center, Lustgarten Laboratory and the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center.
Genes have two alleles, or copies, with one copy inherited from each parent. Cancer-related genetic alterations commonly involve the loss of one of these gene copies. ....

Kenneth Kinzler , Shibin Zhou , Michael Hwang , Bert Vogelstein , Emily Henderson , Ludwig Center , Bloomberg Kimmel Institute For Cancer Immunotherapy , Johns Hopkins Kimmel Cancer Center , Proceedings Of The National Academy Sciences , Johns Hopkins University School Of Medicine , Lustgarten Laboratory , Kimmel Institute , Johns Hopkins Kimmel Cancer , National Academy , Johns Hopkins University School , Brian Mog , Immune Response , ஷிபின் ஜூ , மைக்கேல் ஹ்வ்யாஂக் , பெர்ட் வோகல்ஸ்டீன் , எமிலி ஹென்டர்சன் , லுட்விக் மையம் , ப்ளூம்பெர்க் கீம்மேல் நிறுவனம் க்கு புற்றுநோய் நோயெதிர்ப்பு சிகிச்சை , ஜான்ஸ் ஹாப்கின்ஸ் கீம்மேல் புற்றுநோய் மையம் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , கீம்மேல் நிறுவனம் ,

Genetic variation associated with COVID-19 outcome

Genetic variation associated with COVID-19 outcome
The severity of outcome from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is widely varied, with most individuals remaining asymptomatic while others experience severe life-threatening pneumonia and multi-organ failure. Host genetics play a role in disease progression and prognosis. A paper recently uploaded to the preprint server
et al. (1
st March 2021) identifies several alleles associated with the gene natriuretic peptide receptor C (NPR3) that may impact disease severity.
How was the study performed?
The group worked with 4,488 high-risk COVID-19 outpatients being over 40 years of age and having at least one other comorbidity such as diabetes or obesity. The group was split into two equal sizes, one of which received a placebo, while the other received 0.5 mg colchicine, an anti-inflammatory, daily for a month. The patients were evaluated for disease symptoms 15 and 30 days into ....

Michael Greenwood , Image Credit , Chromosome 9 , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , படம் கடன் , கொரோனா வைரஸ் , நீரிழிவு நோய் , உடல் பருமன் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

New biomarker could help identify people at risk of Alzheimer's disease

Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. ....

Ronald Cowan , Todd Monroe , Ray Romano , Emily Henderson , College Of Graduate Health Sciences , Ohio State University , Nursing Science Program , University Of Tennessee Health Science Center , Alzheimer Association , Nursing Science Phd Program , Tennessee Health Science Center , Graduate Health , Associate Professor Todd Monroe , Alzheimer 39s Disease , Primary Care , ரொனால்ட் கோவன் , டாட் மன்ரோ , ராய் ரோமானோ , எமிலி ஹென்டர்சன் , கல்லூரி ஆஃப் பட்டதாரி ஆரோக்கியம் அறிவியல் , ஓஹியோ நிலை பல்கலைக்கழகம் , நர்சிங் அறிவியல் ப்ரோக்ர்யாம் , பல்கலைக்கழகம் ஆஃப் டென்னசி ஆரோக்கியம் அறிவியல் மையம் , முதுமறதி சங்கம் , நர்சிங் அறிவியல் ஃப்ட் ப்ரோக்ர்யாம் , டென்னசி ஆரோக்கியம் அறிவியல் மையம் ,

Neanderthal gene can confer protection against severe COVID-19, finds study

Neanderthal gene can confer protection against severe COVID-19, finds study
Some of the genes in the human genome appear to confer a protective effect against severe coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A new paper published online in the journal
PNAS describes genes involved in innate immunity that have undergone variations between different human subgroups.
Infectious disease and genetic changes
Infectious diseases vary in prevalence with environmental conditions, which vary dramatically in different parts of the world. These act as selective factors on gene variants, such as the toll-like receptor gene variants that reduce the susceptibility to some bacterial infections and allergies. ....

United States , Liji Thomas , Host Genetics Initiative , Image Credit , South Asia , Critical Care , African Yoruba , Genetics Initiative , Native American , West Nile , Coronavirus Disease Covid 19 , Sars Cov 2 , Chromosome 12 , Chromosome 3 , Corona Virus , Infectious Diseases , Intensive Care , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , தொகுப்பாளர் ஜெநெடிக்ஸ் முயற்சி , படம் கடன் , தெற்கு ஆசியா , முக்கியமான பராமரிப்பு , ஜெநெடிக்ஸ் முயற்சி , பூர்வீகம் அமெரிக்கன் ,

Mitochondrial mutation linked to elevated diabetes risk in Japanese men

A new study of Type 2 diabetes in Japanese populations has uncovered a previously uncharacterized genetic variant that puts male carriers at greater risk for the disease, as well as the mechanism by which it does so. ....

United States , Pinchas Cohen , Su Jeong Kim , Changhan David Lee , Noriyuki Fuku , Emily Henderson , Juntendo University , Leonard Davis School , University Of Southern California , International Diabetes Federation , Southern California , Professor Noriyuki Fuku , East Asian , East Asians , Co Senior Author , Biological Sciences , Davis School , Nature Communication , Multiethnic Cohort , Tohoku Medical Megabank , Physical Activity , Type 2 Diabetes , ஒன்றுபட்டது மாநிலங்களில் , பிஞ்சாக்கள் கோஹன் , சு ஜியோங் கிம் , எமிலி ஹென்டர்சன் ,